Pathology EMQ template.

Name: Fiona Laird

Candidate number:

Theme: Lipoprotein Metabolism

OPTION LIST

A	Apo AI	I	Apo E Receptor
B	Apo AII	J	Familial Combined Hyperlipidaemia
C	Apo AI receptor	K	Familial Hypertriglyceridaemia
D	Apo B100	L	LDL (B/E) Receptor
E	Apo B48	M	Lipoprotein Lipase Deficiency
F	Apo C III	N	Remnant Hyperlipidaemia (Type III Hyperlipidaemia)
G	Apo D	O	Small Dense LDL
H	Apo E	P	VLDL

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. Synthesis of which apo protein is increased in Familial Combined Hyperlipidaemia?

2. Apo E2 homozygosity predisposes to this disease where IDL are raised and chylomicrons are present

3. Dietary triglycerides broken down in the gut are reassembled and combined with this apoprotein to form chylomicrons

4. Chylomicrons from the exogenous lipid metabolism pathway are removed by which receptor in the liver?

5. Activity of which receptor is reduced in Familial Hypercholesterolaemia and Polygenic Hypercholesterolaemia?

ANSWERS

1. D

2. N

3. E

4. I

5. L